Another pickup truck driver here. GMC 1500 4X4 short bed crew cab. I use a tailgate pad, and I’ve had as many as 5 bikes on it. Generally, I can transport 4 riders and gear for a day trip. The short bed doesn’t leave a ton of space to bring anything other than your gear bag and one cooler. Even with the stock tires/rims (I never take off-road) it’s not exactly the most fuel efficient ride in the world. Probably 17mpg highway.
I’ve been a pickup truck driver my whole life, not sure if I could function in any other vehicle.