Check out SanJuanHuts.com. San Jaun Huts does hut to hut bikepacking from Durango to Moab or Telluride to Moab. I’ve done both rides and had a great time. Using their huts makes bikepacking super easy for beginners.
Colorado is so wide-open with possibilities, its hard to single out one particular place. Crested Butte is on everyone’s list, somewhat calendar dependent due to elevation. Grand Junction/Fruita area is drier, lower elevation and also near Moab. Then there are Breckenridge, Durango, Eagle, etc., etc.
I’ve always thought when I finally made it out west for a trip to ride I’d go straight to Moab, but in the past year or two, the more I read about and see photos of Crested Butte, the more I am leaning towards going there instead.
If you have the conditioning and strength, then my opinion is the San Juans Mountains and the Colorado Trail, hands down. Great riding and the most spectacular country in Colorado. Don’t miss the drive from Montrose > Ouray > Silverton > Durango.